Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD/HYPE. The structural basis for BiP binding and AMPylation by FICD has remained elusive due to the tran...

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Detalles Bibliográficos
Autores principales: Fauser, Joel, Gulen, Burak, Pogenberg, Vivian, Pett, Christian, Pourjafar-Dehkordi, Danial, Krisp, Christoph, Höpfner, Dorothea, König, Gesa, Schlüter, Hartmut, Feige, Matthias J., Zacharias, Martin, Hedberg, Christian, Itzen, Aymelt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065156/
https://www.ncbi.nlm.nih.gov/pubmed/33893288
http://dx.doi.org/10.1038/s41467-021-22596-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065156/
https://www.ncbi.nlm.nih.gov/pubmed/33893288
http://dx.doi.org/10.1038/s41467-021-22596-0

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