SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility

Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa mid-piece and show by genetic, biochemical, multi-omic, and nutritional evidenc...

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Detalles Bibliográficos
Autores principales: Kuang, Wenhua, Zhang, Jie, Lan, Zhou, Deepak, R.N.V. Krishna, Liu, Chao, Ma, Zhilong, Cheng, Lili, Zhao, Xinbin, Meng, Xianbin, Wang, Weihua, Wang, Xueying, Xu, Lina, Jiao, Yupei, Luo, Qi, Meng, Ziyi, Kee, Kehkooi, Liu, Xiaohui, Deng, Haiteng, Li, Wei, Fan, Hao, Chen, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065176/
https://www.ncbi.nlm.nih.gov/pubmed/33882315
http://dx.doi.org/10.1016/j.celrep.2021.109025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065176/
https://www.ncbi.nlm.nih.gov/pubmed/33882315
http://dx.doi.org/10.1016/j.celrep.2021.109025

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