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SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility
Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa mid-piece and show by genetic, biochemical, multi-omic, and nutritional evidenc...
Autores principales: | Kuang, Wenhua, Zhang, Jie, Lan, Zhou, Deepak, R.N.V. Krishna, Liu, Chao, Ma, Zhilong, Cheng, Lili, Zhao, Xinbin, Meng, Xianbin, Wang, Weihua, Wang, Xueying, Xu, Lina, Jiao, Yupei, Luo, Qi, Meng, Ziyi, Kee, Kehkooi, Liu, Xiaohui, Deng, Haiteng, Li, Wei, Fan, Hao, Chen, Ligong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065176/ https://www.ncbi.nlm.nih.gov/pubmed/33882315 http://dx.doi.org/10.1016/j.celrep.2021.109025 |
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