Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD

Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PSAPP) exhibit learning and memory deficits at 9 and 1...

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Detalles Bibliográficos
Autores principales: Wang, Shanshan, Leem, Joseph S., Podvin, Sonia, Hook, Vivian, Kleschevnikov, Natalia, Savchenko, Paul, Dhanani, Mehul, Zhou, Kimberly, Kelly, Isabella C., Zhang, Tong, Miyanohara, Atsushi, Nguyen, Phuong, Kleschevnikov, Alexander, Wagner, Steve L., Trojanowski, John Q., Roth, David M., Patel, Hemal H., Patel, Piyush M., Head, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065227/
https://www.ncbi.nlm.nih.gov/pubmed/33981778
http://dx.doi.org/10.1016/j.omtm.2021.03.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065227/
https://www.ncbi.nlm.nih.gov/pubmed/33981778
http://dx.doi.org/10.1016/j.omtm.2021.03.021

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