A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice

Combining amoxicillin with the immunostimulatory toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) represents an innovative approach for enhancing antibacterial treatment success. Exploiting pharmacokinetic and pharmacodynamic data from an infection model of Streptococcus pneumoniae infecte...

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Detalles Bibliográficos
Autores principales: Franck, Sebastian, Michelet, Robin, Casilag, Fiordiligie, Sirard, Jean-Claude, Wicha, Sebastian G., Kloft, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065677/
https://www.ncbi.nlm.nih.gov/pubmed/33808396
http://dx.doi.org/10.3390/pharmaceutics13040469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065677/
https://www.ncbi.nlm.nih.gov/pubmed/33808396
http://dx.doi.org/10.3390/pharmaceutics13040469

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