A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines

Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its fission yeast homologue, Wis1, under oxidative st...

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Detalles Bibliográficos
Autores principales: Otręba, Michał, Sjölander, Johanna Johansson, Grøtli, Morten, Sunnerhagen, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066054/
https://www.ncbi.nlm.nih.gov/pubmed/33807495
http://dx.doi.org/10.3390/life11040297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066054/
https://www.ncbi.nlm.nih.gov/pubmed/33807495
http://dx.doi.org/10.3390/life11040297

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