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Recent Trends in Synthesis of Chloramphenicol New Derivatives
Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has limited clinical potential due to adverse side effects and frequent antimicrobial resistance. Numerous CAM analogs were synthesized...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066525/ https://www.ncbi.nlm.nih.gov/pubmed/33807439 http://dx.doi.org/10.3390/antibiotics10040370 |
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author | Tevyashova, Anna N. |
author_facet | Tevyashova, Anna N. |
author_sort | Tevyashova, Anna N. |
collection | PubMed |
description | Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has limited clinical potential due to adverse side effects and frequent antimicrobial resistance. Numerous CAM analogs were synthesized in order to find the derivatives with improved pharmacological properties and activity on resistant bacterial strains. This work aims to summarize the most recent achievements in obtaining new CAM analogs reported during the last five years. Current investigations are mainly focused on elucidating the molecular basis of the mode of CAM action and determining the mechanisms of resistance to this class of antibiotics or on studies of the possible use of the CAM scaffold to search for therapeutic agents with different CAM modes of action—such as selective antiproliferative agents or bacterial cell wall biosynthesis inhibitors. Hopefully, a deeper understanding of the CAM interactions with the target and its specificity will generate research ideas for developing new effective drugs. |
format | Online Article Text |
id | pubmed-8066525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80665252021-04-25 Recent Trends in Synthesis of Chloramphenicol New Derivatives Tevyashova, Anna N. Antibiotics (Basel) Perspective Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has limited clinical potential due to adverse side effects and frequent antimicrobial resistance. Numerous CAM analogs were synthesized in order to find the derivatives with improved pharmacological properties and activity on resistant bacterial strains. This work aims to summarize the most recent achievements in obtaining new CAM analogs reported during the last five years. Current investigations are mainly focused on elucidating the molecular basis of the mode of CAM action and determining the mechanisms of resistance to this class of antibiotics or on studies of the possible use of the CAM scaffold to search for therapeutic agents with different CAM modes of action—such as selective antiproliferative agents or bacterial cell wall biosynthesis inhibitors. Hopefully, a deeper understanding of the CAM interactions with the target and its specificity will generate research ideas for developing new effective drugs. MDPI 2021-03-31 /pmc/articles/PMC8066525/ /pubmed/33807439 http://dx.doi.org/10.3390/antibiotics10040370 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Tevyashova, Anna N. Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title | Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title_full | Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title_fullStr | Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title_full_unstemmed | Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title_short | Recent Trends in Synthesis of Chloramphenicol New Derivatives |
title_sort | recent trends in synthesis of chloramphenicol new derivatives |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066525/ https://www.ncbi.nlm.nih.gov/pubmed/33807439 http://dx.doi.org/10.3390/antibiotics10040370 |
work_keys_str_mv | AT tevyashovaannan recenttrendsinsynthesisofchloramphenicolnewderivatives |