Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance

Multidrug resistance (MDR) is a common problem when fighting cancer with chemotherapy. P-glycoprotein (P-gp, or MDR1) is an active pump responsible for the efflux of xenobiotics out of the cell, including anti-cancer drugs. It is a validated target against MDR. No crystal structure of the human P-gp...

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Detalles Bibliográficos
Autores principales: Marques, Sérgio M., Šupolíková, Lucie, Molčanová, Lenka, Šmejkal, Karel, Bednar, David, Slaninová, Iva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066904/
https://www.ncbi.nlm.nih.gov/pubmed/33808505
http://dx.doi.org/10.3390/biomedicines9040357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066904/
https://www.ncbi.nlm.nih.gov/pubmed/33808505
http://dx.doi.org/10.3390/biomedicines9040357

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