Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology

Sirolimus is widely used in transplantation, where its therapeutic drug monitoring (TDM) is well established. Evidence of a crucial role for sirolimus in the PI3K/AkT/mTor pathway has stimulated interest in its involvement in neoplasia, either as monotherapy or in combination with other antineoplast...

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Detalles Bibliográficos
Autores principales: Sabo, Amelia-Naomi, Jannier, Sarah, Becker, Guillaume, Lessinger, Jean-Marc, Entz-Werlé, Natacha, Kemmel, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067051/
https://www.ncbi.nlm.nih.gov/pubmed/33808416
http://dx.doi.org/10.3390/pharmaceutics13040470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067051/
https://www.ncbi.nlm.nih.gov/pubmed/33808416
http://dx.doi.org/10.3390/pharmaceutics13040470

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