Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experiment...

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Detalles Bibliográficos
Autores principales: Toropainen, Elisa, Fraser-Miller, Sara J., Novakovic, Dunja, Del Amo, Eva M., Vellonen, Kati-Sisko, Ruponen, Marika, Viitala, Tapani, Korhonen, Ossi, Auriola, Seppo, Hellinen, Laura, Reinisalo, Mika, Tengvall, Unni, Choi, Stephanie, Absar, Mohammad, Strachan, Clare, Urtti, Arto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067094/
https://www.ncbi.nlm.nih.gov/pubmed/33810564
http://dx.doi.org/10.3390/pharmaceutics13040452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067094/
https://www.ncbi.nlm.nih.gov/pubmed/33810564
http://dx.doi.org/10.3390/pharmaceutics13040452

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