Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs

Influenza viruses with an impaired NS1 protein are unable to antagonize the innate immune system and, therefore, are highly immunogenic because of the self-adjuvating effect. Hence, NS1-mutated viruses are considered promising candidates for the development of live-attenuated influenza vaccines and...

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Detalles Bibliográficos
Autores principales: Vasilyev, Kirill, Shurygina, Anna-Polina, Sergeeva, Maria, Stukova, Marina, Egorov, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067201/
https://www.ncbi.nlm.nih.gov/pubmed/33810549
http://dx.doi.org/10.3390/microorganisms9040690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067201/
https://www.ncbi.nlm.nih.gov/pubmed/33810549
http://dx.doi.org/10.3390/microorganisms9040690

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