Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a

In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative regulator of p53. We evaluated PPM1D expression and explored the therapeutic efficacy of WIP1 inhibitor (WIP1i) GSK2830371, in...

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Detalles Bibliográficos
Autores principales: Fontana, Maria Chiara, Nanni, Jacopo, Ghelli Luserna di Rorà, Andrea, Petracci, Elisabetta, Padella, Antonella, Ghetti, Martina, Ferrari, Anna, Marconi, Giovanni, Soverini, Simona, Iacobucci, Ilaria, Papayannidis, Cristina, Curti, Antonio, Audisio, Ernesta, Giannini, Maria Benedetta, Rondoni, Michela, Lanza, Francesco, Cavo, Michele, Martinelli, Giovanni, Simonetti, Giorgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067413/
https://www.ncbi.nlm.nih.gov/pubmed/33917342
http://dx.doi.org/10.3390/biomedicines9040388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067413/
https://www.ncbi.nlm.nih.gov/pubmed/33917342
http://dx.doi.org/10.3390/biomedicines9040388

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