Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance

Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability. Here, we attempted to improve CC’s bioavailability by formulating several CC-loaded amorphous solid dispersions with a hydrophilic carrier (PVPK30)...

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Detalles Bibliográficos
Autores principales: Poudel, Surendra, Kim, Dong Wuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067465/
https://www.ncbi.nlm.nih.gov/pubmed/33917403
http://dx.doi.org/10.3390/pharmaceutics13040497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067465/
https://www.ncbi.nlm.nih.gov/pubmed/33917403
http://dx.doi.org/10.3390/pharmaceutics13040497

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