Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice. As α7 nAChRs are implicated in the “Cholinergic anti-inflammatory pathway”, we aimed to determine how α7 nAChR stimulation modulates micr...

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Detalles Bibliográficos
Autores principales: Navarro, Elisa, Norden, Diana M., Trojanowski, Paige J., Godbout, Jonathan P., López, Manuela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067582/
https://www.ncbi.nlm.nih.gov/pubmed/33916910
http://dx.doi.org/10.3390/molecules26082107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067582/
https://www.ncbi.nlm.nih.gov/pubmed/33916910
http://dx.doi.org/10.3390/molecules26082107

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