Identification of Flavonoids as Putative ROS-1 Kinase Inhibitors Using Pharmacophore Modeling for NSCLC Therapeutics

Non-small cell lung cancer (NSCLC) is a lethal non-immunogenic malignancy and proto-oncogene ROS-1 tyrosine kinase is one of its clinically relevant oncogenic markers. The ROS-1 inhibitor, crizotinib, demonstrated resistance due to the Gly2032Arg mutation. To curtail this resistance, researchers dev...

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Detalles Bibliográficos
Autores principales: Parate, Shraddha, Kumar, Vikas, Hong, Jong Chan, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067712/
https://www.ncbi.nlm.nih.gov/pubmed/33917039
http://dx.doi.org/10.3390/molecules26082114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067712/
https://www.ncbi.nlm.nih.gov/pubmed/33917039
http://dx.doi.org/10.3390/molecules26082114

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