Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its struct...

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Detalles Bibliográficos
Autores principales: Kayushin, Alexey L., Tokunova, Julia A., Fateev, Ilja V., Arnautova, Alexandra O., Berzina, Maria Ya., Paramonov, Alexander S., Lutonina, Olga I., Dorofeeva, Elena V., Antonov, Konstantin V., Esipov, Roman S., Mikhailopulo, Igor A., Miroshnikov, Anatoly I., Konstantinova, Irina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067715/
https://www.ncbi.nlm.nih.gov/pubmed/33917025
http://dx.doi.org/10.3390/biom11040539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067715/
https://www.ncbi.nlm.nih.gov/pubmed/33917025
http://dx.doi.org/10.3390/biom11040539

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