Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis

A series of coumarin-linked 4-anilinomethyl-1,2,3-triazoles (6a–t) was synthesized via a molecular hybridization approach, through carbon C-6 of the coumarin moiety. The synthesized compounds were evaluated for their inhibition of carbonic anhydrase (CA) isoforms I, II, IX and XIII. CAs IX and XIII...

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Detalles Bibliográficos
Autores principales: Thacker, Pavitra S., Tiwari, Prerna L., Angeli, Andrea, Srikanth, Danaboina, Swain, Baijayantimala, Arifuddin, Mohammed, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067737/
https://www.ncbi.nlm.nih.gov/pubmed/33917033
http://dx.doi.org/10.3390/metabo11040225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067737/
https://www.ncbi.nlm.nih.gov/pubmed/33917033
http://dx.doi.org/10.3390/metabo11040225

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