Cargando…

Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells

1,2-unsaturated pyrrolizidine alkaloids (PAs) are secondary plant metabolites occurring as food contaminants that can cause severe liver damage upon metabolic activation in hepatocytes. However, it is yet unknown how these contaminants enter the cells. The role of hepatic transporters is only at the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Enge, Anne-Margarethe, Kaltner, Florian, Gottschalk, Christoph, Braeuning, Albert, Hessel-Pras, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067754/ https://www.ncbi.nlm.nih.gov/pubmed/33917053 http://dx.doi.org/10.3390/ijms22083821

Ejemplares similares

Pyrrolizidine Alkaloids Induce Cell Death in Human HepaRG Cells in a Structure-Dependent Manner
por: Glück, Josephin, et al.
Publicado: (2020)

Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG
por: Waizenegger, Julia, et al.
Publicado: (2021)

Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells
por: Enge, Anne-Margarethe, et al.
Publicado: (2022)

The Food Contaminants Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis Structure-Dependently in the Human Hepatoma Cell Line HepaRG
por: Glück, Josephin, et al.
Publicado: (2021)

Structure-Dependent Toxicokinetics of Selected Pyrrolizidine Alkaloids In Vitro
por: Buchmueller, Julia, et al.
Publicado: (2022)

Toxic Prediction of Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells
por: Zheng, Pimiao, et al.
Publicado: (2021)

Okadaic acid influences xenobiotic metabolism in HepaRG cells
por: Wuerger, Leonie T.D., et al.
Publicado: (2022)

Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
por: Ebmeyer, Johanna, et al.
Publicado: (2020)

RNA-protein correlation of liver toxicity markers in HepaRG cells
por: Braeuning, Albert, et al.
Publicado: (2020)

Proteomic analysis of hepatic effects of okadaic acid in HepaRG human liver cells
por: Wuerger, Leonie T.D., et al.
Publicado: (2023)

The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells
por: Zárybnický, Tomáš, et al.
Publicado: (2020)

Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells
por: Wuerger, Leonie T. D., et al.
Publicado: (2023)

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells
por: Behr, Anne-Cathrin, et al.
Publicado: (2020)

More than additive effects on liver triglyceride accumulation by combinations of steatotic and non-steatotic pesticides in HepaRG cells
por: Lasch, Alexandra, et al.
Publicado: (2021)

Comparative Analysis of Transcriptional Responses to Genotoxic and Non-Genotoxic Agents in the Blood Cell Model TK6 and the Liver Model HepaRG
por: Kreuzer, Katrin, et al.
Publicado: (2022)

Evaluation of the impact of matrix stiffness on encapsulated HepaRG spheroids
por: Rebelo, Sofia P, et al.
Publicado: (2013)

Evaluation of a novel PXR‐knockout in HepaRG(™) cells
por: Williamson, Beth, et al.
Publicado: (2016)

Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells
por: Dubois-Pot-Schneider, Hélène, et al.
Publicado: (2022)

mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells
por: Mayati, Abdullah, et al.
Publicado: (2018)

Functional polarization of human hepatoma HepaRG cells in response to forskolin
por: Mayati, Abdullah, et al.
Publicado: (2018)

Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
por: Buchmueller, Julia, et al.
Publicado: (2021)

Occurrence and Risk Assessment of Pyrrolizidine Alkaloids in Spices and Culinary Herbs from Various Geographical Origins
por: Kaltner, Florian, et al.
Publicado: (2020)

Protective effects of an ethanol extract of Angelica keiskei against acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells
por: Choi, Yoon-Hee, et al.
Publicado: (2017)

Comparison of Human Hepatoma HepaRG Cells with Human and Rat Hepatocytes in Uptake Transport Assays in Order to Predict a Risk of Drug Induced Hepatotoxicity
por: Szabo, Monika, et al.
Publicado: (2013)

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
por: Doktorova, T. Y., et al.
Publicado: (2014)

Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)
por: Biales, Adam D., et al.
Publicado: (2020)

The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells
por: Fan, Weiyang, et al.
Publicado: (2021)

Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
por: Louisse, Jochem, et al.
Publicado: (2023)

Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells
por: Lynch, Katherine D., et al.
Publicado: (2023)

Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism
por: Wang, Ziqi, et al.
Publicado: (2021)

Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells
por: Sokolowska, Izabela, et al.
Publicado: (2012)

Analysis of Mitochondrial DNA Polymorphisms in the Human Cell Lines HepaRG and SJCRH30
por: Young, Matthew J., et al.
Publicado: (2019)

Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice
por: Kim, Jin, et al.
Publicado: (2020)

Fast Differentiation of HepaRG Cells Allowing Hepatitis B and Delta Virus Infections
por: Lucifora, Julie, et al.
Publicado: (2020)

A first experience of transduction for differentiated HepaRG cells using lentiviral technology
por: Pivert, Adeline, et al.
Publicado: (2019)

Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor
por: Baca, Martin, et al.
Publicado: (2022)

A sensitive LC–MS/MS method for isomer separation and quantitative determination of 51 pyrrolizidine alkaloids and two tropane alkaloids in cow’s milk
por: Klein, Lisa Monika, et al.
Publicado: (2022)

Correction to: A sensitive LC–MS/MS method for isomer separation and quantitative determination of 51 pyrrolizidine alkaloids and two tropane alkaloids in cow’s milk
por: Klein, Lisa Monika, et al.
Publicado: (2022)

3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells
por: Takahashi, Yu, et al.
Publicado: (2015)

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line
por: You, Longtai, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7tg565icoc7qmtuhn1kqvv65nq