Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells

A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetylcholinesterase (AChE, IC(50) = 6.30 µM) and butyrylc...

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Detalles Bibliográficos
Autores principales: Hudáčová, Monika, Hamuľaková, Slávka, Konkoľová, Eva, Jendželovský, Rastislav, Vargová, Jana, Ševc, Juraj, Fedoročko, Peter, Soukup, Ondrej, Janočková, Jana, Ihnatova, Veronika, Kučera, Tomáš, Bzonek, Petr, Novakova, Nikola, Jun, Daniel, Junova, Lucie, Korábečný, Jan, Kuča, Kamil, Kožurková, Mária
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068036/
https://www.ncbi.nlm.nih.gov/pubmed/33917200
http://dx.doi.org/10.3390/ijms22083830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068036/
https://www.ncbi.nlm.nih.gov/pubmed/33917200
http://dx.doi.org/10.3390/ijms22083830

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