Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer

SIMPLE SUMMARY: Pancreatic cancer has the worst survival of any human cancer. Checkpoint blockade has not yielded much benefit in pancreatic cancer. We explored immune cell phenotypes with this disease to identify new targets for checkpoint blockade therapy. We created a checkpoint-focused panel to...

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Detalles Bibliográficos
Autores principales: Sivakumar, Shivan, Abu-Shah, Enas, Ahern, David J., Arbe-Barnes, Edward H., Jainarayanan, Ashwin K., Mangal, Nagina, Reddy, Srikanth, Rendek, Aniko, Easton, Alistair, Kurz, Elke, Silva, Michael, Soonawalla, Zahir, Heij, Lara R., Bashford-Rogers, Rachael, Middleton, Mark R., Dustin, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068251/
https://www.ncbi.nlm.nih.gov/pubmed/33917832
http://dx.doi.org/10.3390/cancers13081776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068251/
https://www.ncbi.nlm.nih.gov/pubmed/33917832
http://dx.doi.org/10.3390/cancers13081776

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