Investigation of the Differences in Antithrombin to Heparin Binding among Antithrombin Budapest 3, Basel, and Padua Mutations by Biochemical and In Silico Methods

Antithrombin (AT) is a serine protease inhibitor, its activity is highly accelerated by heparin. Mutations at the heparin-binding region lead to functional defect, type II heparin-binding site (IIHBS) AT deficiency. The aim of this study was to investigate and compare the molecular background of AT...

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Detalles Bibliográficos
Autores principales: Gindele, Réka, Pénzes-Daku, Krisztina, Balogh, Gábor, Kállai, Judit, Bogáti, Réka, Bécsi, Bálint, Erdődi, Ferenc, Katona, Éva, Bereczky, Zsuzsanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068293/
https://www.ncbi.nlm.nih.gov/pubmed/33917853
http://dx.doi.org/10.3390/biom11040544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068293/
https://www.ncbi.nlm.nih.gov/pubmed/33917853
http://dx.doi.org/10.3390/biom11040544

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