Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two s...

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Detalles Bibliográficos
Autores principales: Oh, Youri, Jung, Hoyong, Kim, Hyejin, Baek, Jihyun, Jun, Joonhong, Cho, Hyunwook, Im, Daseul, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068361/
https://www.ncbi.nlm.nih.gov/pubmed/33917995
http://dx.doi.org/10.3390/ijms22083865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068361/
https://www.ncbi.nlm.nih.gov/pubmed/33917995
http://dx.doi.org/10.3390/ijms22083865

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