Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain

The vast majority of coagulation factor VII (FVII), a trypsin-like protease, circulates as the inactive zymogen. Activated FVII (FVIIa) is formed upon proteolytic activation of FVII, where it remains in a zymogen-like state and it is fully activated only when bound to tissue factor (TF). The catalyt...

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Detalles Bibliográficos
Autores principales: Madsen, Jesper J., Olsen, Ole H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068379/
https://www.ncbi.nlm.nih.gov/pubmed/33917935
http://dx.doi.org/10.3390/biom11040549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068379/
https://www.ncbi.nlm.nih.gov/pubmed/33917935
http://dx.doi.org/10.3390/biom11040549

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