Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease

Significance: The majority of the drugs which target membrane-embedded protease γ-secretase show an unusual biphasic activation–inhibition dose-response in cells, model animals, and humans. Semagacestat and avagacestat are two biphasic drugs that can facilitate cognitive decline in patients with Alz...

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Detalles Bibliográficos
Autores principales: Svedružić, Željko M., Vrbnjak, Katarina, Martinović, Manuel, Miletić, Vedran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068388/
https://www.ncbi.nlm.nih.gov/pubmed/33917979
http://dx.doi.org/10.3390/pharmaceutics13040514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068388/
https://www.ncbi.nlm.nih.gov/pubmed/33917979
http://dx.doi.org/10.3390/pharmaceutics13040514

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