Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells

Inducing apoptosis is an effective treatment for cancer. Conventional cytotoxic anticancer agents induce apoptosis primarily through activation of tumor suppressor p53 by causing DNA damage and the resulting regulation of B-cell leukemia/lymphoma-2 (BCL-2) family proteins. Therefore, the effects of...

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Detalles Bibliográficos
Autores principales: Nakajima, Wataru, Miyazaki, Kai, Asano, Yumi, Kubota, Satoshi, Tanaka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068402/
https://www.ncbi.nlm.nih.gov/pubmed/33918002
http://dx.doi.org/10.3390/genes12040539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068402/
https://www.ncbi.nlm.nih.gov/pubmed/33918002
http://dx.doi.org/10.3390/genes12040539

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