The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles

Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nef(mut) fused at its C-terminus to viral and tumor antigens elicit a potent, effective, and anti-tolerogenic CD8(+) T cell immunity against the heterologous antigen. The immune response is induced thr...

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Detalles Bibliográficos
Autores principales: Chiozzini, Chiara, Manfredi, Francesco, Ferrantelli, Flavia, Leone, Patrizia, Giovannelli, Andrea, Olivetta, Eleonora, Federico, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068889/
https://www.ncbi.nlm.nih.gov/pubmed/33921215
http://dx.doi.org/10.3390/vaccines9040373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068889/
https://www.ncbi.nlm.nih.gov/pubmed/33921215
http://dx.doi.org/10.3390/vaccines9040373

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