Cargando…

The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling

SIMPLE SUMMARY: Proliferation of glioblastoma (GBM) depends on access to extracellular nutrients. Inadequate tumor perfusion creates a short supply of the most common nutrients, such as glucose (Glc) and glutamine. As a result, GBMs undergo metabolic remodeling and scavenge alternative nutrients fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharpe, Martyn A., Ijare, Omkar B., Baskin, David S., Baskin, Alexandra M., Baskin, Brianna N., Pichumani, Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069026/ https://www.ncbi.nlm.nih.gov/pubmed/33920278 http://dx.doi.org/10.3390/cancers13081815

Ejemplares similares

FSMP-02. CHANGES IN GLUTAMINE METABOLISM INDUCED BY OXALOACETATE IN GLIOBLASTOMA
por: Ijare, Omkar, et al.
Publicado: (2021)

Proton Magnetic Resonance Spectroscopy Characterization of Rathke’s Cleft Cysts (RCCs): Relevance to the Differential Diagnosis of Pituitary Adenomas and RCCs
por: Ijare, Omkar B., et al.
Publicado: (2020)

Ex Vivo(1)H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes
por: Ijare, Omkar B., et al.
Publicado: (2019)

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
por: Sharpe, Martyn A., et al.
Publicado: (2021)

Elevated levels of circulating betahydroxybutyrate in pituitary tumor patients may differentiate prolactinomas from other immunohistochemical subtypes
por: Ijare, Omkar B., et al.
Publicado: (2020)

A ”Clickable” Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT
por: Raghavan, Sudhir, et al.
Publicado: (2020)

PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma
por: Sharpe, Martyn A., et al.
Publicado: (2018)

Hijacking Sexual Immuno-Privilege in GBM—An Immuno-Evasion Strategy
por: Sharpe, Martyn A., et al.
Publicado: (2021)

Acquisition of Immune Privilege in GBM Tumors: Role of Prostaglandins and Bile Salts
por: Sharpe, Martyn A., et al.
Publicado: (2023)

Awakening the endogenous Leloir pathway for efficient galactose utilization by Yarrowia lipolytica
por: Lazar, Zbigniew, et al.
Publicado: (2015)

Case Report: End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic Device
por: Baskin, David S., et al.
Publicado: (2021)

Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3
por: Sharpe, Martyn A., et al.
Publicado: (2015)

OTME-10. Integrated analysis of human gliomas at the single cell level identifies S100A4 as a novel immunotherapy target
por: Abdelfattah, Nourhan, et al.
Publicado: (2021)

Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug
por: Sharpe, Martyn A., et al.
Publicado: (2015)

Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA
por: Sharpe, Martyn A., et al.
Publicado: (2012)

B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal
por: Sharpe, Martyn A., et al.
Publicado: (2013)

Alterations in Sensitivity to Estrogen, Dihydrotestosterone, and Xenogens in B-Lymphocytes from Children with Autism Spectrum Disorder and Their Unaffected Twins/Siblings
por: Sharpe, Martyn A., et al.
Publicado: (2013)

Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
por: Hambarde, Shashank, et al.
Publicado: (2023)

Breaking Seed Dormancy during Dry Storage: A Useful Tool or Major Problem for Successful Restoration via Direct Seeding?
por: Baskin, Carol C., et al.
Publicado: (2020)

Leloir Glycosyltransferases in Applied Biocatalysis: A Multidisciplinary Approach
por: Mestrom, Luuk, et al.
Publicado: (2019)

GlaR (YugA)—a novel RpiR‐family transcription activator of the Leloir pathway of galactose utilization in Lactococcus lactis IL1403
por: Aleksandrzak‐Piekarczyk, Tamara, et al.
Publicado: (2018)

The gene doctors: medical genetics at the frontier
por: Baskin, Yvonne
Publicado: (1984)

Google Talking
por: Baskin, Brian
Publicado: (2006)

Increasing influenza vaccination rates via low cost messaging interventions
por: Baskin, Ernest
Publicado: (2018)

Seed dormancy and germination of the endangered exceptional Hawaiian lobelioid Brighamia rockii
por: Wolkis, Dustin, et al.
Publicado: (2022)

Editorial: Metabolic regulation in cardiovascular homeostasis and disease
por: Song, Kunhua, et al.
Publicado: (2022)

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
por: Abdelfattah, Nourhan, et al.
Publicado: (2022)

Seed position in spikelet as a contributing factor to the success of the winter annual invasive grass Aegilops tauschii
por: Wang, AiBo, et al.
Publicado: (2022)

The heart-liver metabolic axis: defective communication exacerbates disease
por: Baskin, Kedryn K, et al.
Publicado: (2014)

Seeds : ecology, biogeography, and evolution of dormancy and germination /
por: Baskin, Carol C.
Publicado: (2001)

The Variation of Muscle Oxygen Consumption With Velocity of Shortening
por: Baskin, R. J.
Publicado: (1965)

ULTRASTRUCTURE AND CALCIUM TRANSPORT IN CRUSTACEAN MUSCLE MICROSOMES
por: Baskin, R. J.
Publicado: (1971)

Recent Advances in Urology
por: Baskin, Arnold M.
Publicado: (1958)

Clinical Proteomics of Breast Cancer
por: Baskın, Y., et al.
Publicado: (2010)

Fibrinogen Chains Intrinsic to the Brain
por: Golanov, Eugene V., et al.
Publicado: (2019)

Seed Mucilage Improves Seedling Emergence of a Sand Desert Shrub
por: Yang, Xuejun, et al.
Publicado: (2012)

Germination Season and Watering Regime, but Not Seed Morph, Affect Life History Traits in a Cold Desert Diaspore-Heteromorphic Annual
por: Lu, Juan J., et al.
Publicado: (2014)

Effects of germination season on life history traits and on transgenerational plasticity in seed dormancy in a cold desert annual
por: Lu, Juan J., et al.
Publicado: (2016)

Effect of Seed Position on Parental Plant on Proportion of Seeds Produced with Nondeep and Intermediate Physiological Dormancy
por: Lu, Juan J., et al.
Publicado: (2017)

Effects of Litter on Seedling Emergence and Seed Persistence of Three Common Species on the Loess Plateau in Northwestern China
por: Zhang, Rui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mes41df3kvjtvfr1sj2ut4bjqs