Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism

The intervertebral disc is the largest avascular organ. Autophagy is an important cell survival mechanism by self-digestion and recycling damaged components under stress, primarily nutrient deprivation. Resident cells would utilize autophagy to cope with the harsh disc environment. Our objective was...

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Detalles Bibliográficos
Autores principales: Ito, Masaaki, Yurube, Takashi, Kanda, Yutaro, Kakiuchi, Yuji, Takeoka, Yoshiki, Takada, Toru, Kuroda, Ryosuke, Kakutani, Kenichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069032/
https://www.ncbi.nlm.nih.gov/pubmed/33921398
http://dx.doi.org/10.3390/ijms22083965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069032/
https://www.ncbi.nlm.nih.gov/pubmed/33921398
http://dx.doi.org/10.3390/ijms22083965

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