Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total

A sequential pharmacokinetic (PK) and pharmacodynamic (PD) model was built with Nonlinear Mixed Effects Modelling based on data from a first-in-human trial of a novel biologic, MEDI7836. MEDI7836 is a human immunoglobulin G1 lambda (IgG1λ-YTE) monoclonal antibody, with an Fc modification to reduce m...

Descripción completa

Detalles Bibliográficos
Autores principales: Hood, John, González-García, Ignacio, White, Nicholas, Marshall, Leeron, Dubois, Vincent F. S., Vicini, Paolo, Baverel, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069034/
https://www.ncbi.nlm.nih.gov/pubmed/33918602
http://dx.doi.org/10.3390/pharmaceutics13040519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069034/
https://www.ncbi.nlm.nih.gov/pubmed/33918602
http://dx.doi.org/10.3390/pharmaceutics13040519

Ejemplares similares