Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods

dHG-5 (Mw 5.3 kD) is a depolymerized glycosaminoglycan from sea cucumber Holothuria fuscopunctata. As a selective inhibitor of intrinsic Xase (iXase), preclinical study showed it was a promising anticoagulant candidate without obvious bleeding risk. In this work, two bioanalytical methods based on t...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Zhang, Taocui, Sun, Huifang, Lin, Lisha, Gao, Na, Wang, Weili, Li, Sujuan, Zhao, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069088/
https://www.ncbi.nlm.nih.gov/pubmed/33920475
http://dx.doi.org/10.3390/md19040212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069088/
https://www.ncbi.nlm.nih.gov/pubmed/33920475
http://dx.doi.org/10.3390/md19040212

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