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CRISPR-Induced Expression of N-Terminally Truncated Dicer in Mouse Cells

RNA interference (RNAi) designates sequence-specific mRNA degradation mediated by small RNAs generated from long double-stranded RNA (dsRNA) by RNase III Dicer. RNAi appears inactive in mammalian cells except for mouse oocytes, where high RNAi activity exists because of an N-terminally truncated Dic...

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Detalles Bibliográficos
Autores principales: Malik, Radek, Svoboda, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069103/
https://www.ncbi.nlm.nih.gov/pubmed/33918028
http://dx.doi.org/10.3390/genes12040540