Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Screening, Biochemical Evaluation and Molecular Modeling Studies

Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynthesis of mediators in inflammation and allergic reactions, was selected for a biochemical screening campaign to identify LOX inhibitors by employing t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeraik, Maria Luiza, Pauli, Ivani, Dutra, Luiz A., Cruz, Raquel S., Valli, Marilia, Paracatu, Luana C., de Faria, Carolina M. Q. G., Ximenes, Valdecir F., Regasini, Luis O., Andricopulo, Adriano D., Bolzani, Vanderlan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069166/
https://www.ncbi.nlm.nih.gov/pubmed/33921198
http://dx.doi.org/10.3390/molecules26082205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069166/
https://www.ncbi.nlm.nih.gov/pubmed/33921198
http://dx.doi.org/10.3390/molecules26082205

Ejemplares similares