Cargando…

Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Screening, Biochemical Evaluation and Molecular Modeling Studies

Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynthesis of mediators in inflammation and allergic reactions, was selected for a biochemical screening campaign to identify LOX inhibitors by employing t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeraik, Maria Luiza, Pauli, Ivani, Dutra, Luiz A., Cruz, Raquel S., Valli, Marilia, Paracatu, Luana C., de Faria, Carolina M. Q. G., Ximenes, Valdecir F., Regasini, Luis O., Andricopulo, Adriano D., Bolzani, Vanderlan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069166/ https://www.ncbi.nlm.nih.gov/pubmed/33921198 http://dx.doi.org/10.3390/molecules26082205

Ejemplares similares

Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification
por: Zeraik, Maria Luiza, et al.
Publicado: (2014)

Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2014)

Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery
por: Valli, Marilia, et al.
Publicado: (2022)

NuBBE(DB): an updated database to uncover chemical and biological information from Brazilian biodiversity
por: Pilon, Alan C., et al.
Publicado: (2017)

Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
por: Chapla, Vanessa Mara, et al.
Publicado: (2014)

Apocynin: Chemical and Biophysical Properties of a NADPH Oxidase Inhibitor
por: Petrônio, Maicon S., et al.
Publicado: (2013)

Experimental and quantum chemical studies of a novel synthetic prenylated chalcone
por: Espinoza-Hicks, José C, et al.
Publicado: (2013)

Effects of Microbial Transformation on the Biological Activities of Prenylated Chalcones from Angelica keiskei
por: Xiao, Yina, et al.
Publicado: (2022)

Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel
por: Fonseca, Joana, et al.
Publicado: (2016)

Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca
por: Chapla, Vanessa Mara, et al.
Publicado: (2014)

Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis
por: Ban, Zhaonan, et al.
Publicado: (2018)

Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells
por: Seitz, Tatjana, et al.
Publicado: (2021)

Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors
por: Georgiou, Nikitas, et al.
Publicado: (2023)

Inhibition of Oxidative Stress and Skin Aging-Related Enzymes by Prenylated Chalcones and Other Flavonoids from Helichrysum teretifolium
por: Popoola, Olugbenga K., et al.
Publicado: (2015)

Exploring the 2′-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents
por: Kostopoulou, Ioanna, et al.
Publicado: (2021)

Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)
por: Coqueiro, Aline, et al.
Publicado: (2013)

Hierarchical Clustering and Target-Independent QSAR for Antileishmanial Oxazole and Oxadiazole Derivatives
por: Teles, Henrique R., et al.
Publicado: (2022)

Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells
por: Liu, Ming, et al.
Publicado: (2016)

Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
por: Lopes, Flávia CM, et al.
Publicado: (2009)

Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis
por: Budziak, Iwona, et al.
Publicado: (2019)

Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A
por: Morão, Luana G., et al.
Publicado: (2020)

Navigating the Chemical Space and Chemical Multiverse of a Unified Latin American Natural Product Database: LANaPDB
por: Gómez-García, Alejandro, et al.
Publicado: (2023)

Chalcone Derivatives 4′-Amino-1-Naphthyl-Chalcone (D14) and 4′-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes
por: Seba, Viviane, et al.
Publicado: (2018)

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A(2), cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
por: Jantan, Ibrahim, et al.
Publicado: (2014)

Erythrina mulungu Alkaloids Are Potent Inhibitors of Neuronal Nicotinic Receptor Currents in Mammalian Cells
por: Setti-Perdigão, Pedro, et al.
Publicado: (2013)

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2020)

Investigation of Human Albumin-Induced Circular Dichroism in Dansylglycine
por: Graciani, Fernanda S., et al.
Publicado: (2013)

A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
por: Martin, Andreas, et al.
Publicado: (2023)

Chalcone T4 Inhibits RANKL-Induced Osteoclastogenesis and Stimulates Osteogenesis In Vitro
por: de Matos, Iolanda Augusta Fernandes, et al.
Publicado: (2023)

Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives
por: Chang, Xuexue, et al.
Publicado: (2023)

Taurine Bromamine: Reactivity of an Endogenous and Exogenous Anti-Inflammatory and Antimicrobial Amino Acid Derivative
por: Bertozo, Luiza De Carvalho, et al.
Publicado: (2016)

Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation
por: Bertozo, Luiza de Carvalho, et al.
Publicado: (2018)

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
por: Cardoso-Lopes, Elaine Monteiro, et al.
Publicado: (2010)

Molecular Basis for Rab Prenylation
por: Alory, Christelle, et al.
Publicado: (2000)

Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics
por: Storck, Elisabeth M., et al.
Publicado: (2019)

Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide
por: Mustedanagic, Jasmin, et al.
Publicado: (2017)

Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams
por: Nazaré, Ana C., et al.
Publicado: (2014)

Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria
por: Pinto, Meri Emili F., et al.
Publicado: (2018)

Refinement and prediction of protein prenylation motifs
por: Maurer-Stroh, Sebastian, et al.
Publicado: (2005)

Antitumor Activity of Some Prenylated Xanthones
por: Castanheiro, Raquel A. P., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_tjqv8icj263nj9ipdc2q04popi