Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

The dopamine D2/D3 receptor (D(2)R/D(3)R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D(3)R over D(2)R is attractive because of D(3)R’s restricted tissue distribution with potentially fewer side-effects and its putative neuroprotec...

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Detalles Bibliográficos
Autores principales: Adhikari, Pramisha, Xie, Bing, Semeano, Ana, Bonifazi, Alessandro, Battiti, Francisco O., Newman, Amy H., Yano, Hideaki, Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069330/
https://www.ncbi.nlm.nih.gov/pubmed/33924613
http://dx.doi.org/10.3390/biom11040570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069330/
https://www.ncbi.nlm.nih.gov/pubmed/33924613
http://dx.doi.org/10.3390/biom11040570

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