Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress

DNA can experience “replication stress”, an important source of genome instability, induced by various external or endogenous impediments that slow down or stall DNA synthesis. While genome instability is largely documented to favor both tumor formation and heterogeneity, as well as drug resistance,...

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Detalles Bibliográficos
Autores principales: Maiorano, Domenico, El Etri, Jana, Franchet, Camille, Hoffmann, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069355/
https://www.ncbi.nlm.nih.gov/pubmed/33920223
http://dx.doi.org/10.3390/ijms22083924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069355/
https://www.ncbi.nlm.nih.gov/pubmed/33920223
http://dx.doi.org/10.3390/ijms22083924

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