Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition

SIMPLE SUMMARY: Mutations in RAS-family genes frequently cause different types of human cancers. Inhibitors of the MEK (mitogen-activated protein kinase) and ERK (extracellular signal-regulated kinase) protein kinases that function downstream of RAS proteins have shown some clinical benefits when us...

Descripción completa

Detalles Bibliográficos
Autores principales: Catalano, Antonella, Adlesic, Mojca, Kaltenbacher, Thorsten, Klar, Rhena F. U., Albers, Joachim, Seidel, Philipp, Brandt, Laura P., Hejhal, Tomas, Busenhart, Philipp, Röhner, Niklas, Zodel, Kyra, Fritsch, Kornelia, Wild, Peter J., Duyster, Justus, Fritsch, Ralph, Brummer, Tilman, Frew, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069437/
https://www.ncbi.nlm.nih.gov/pubmed/33924486
http://dx.doi.org/10.3390/cancers13081852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069437/
https://www.ncbi.nlm.nih.gov/pubmed/33924486
http://dx.doi.org/10.3390/cancers13081852

Ejemplares similares