Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity

A promising strategy to neutralize HIV-1 is to target the gp41 spike subunit to block membrane fusion with the cell. We previously designed a series of single-chain proteins (named covNHR) that mimic the trimeric coiled-coil structure of the gp41 N-terminal heptad repeat (NHR) region and potently in...

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Detalles Bibliográficos
Autores principales: Cano-Muñoz, Mario, Cesaro, Samuele, Morel, Bertrand, Lucas, Julie, Moog, Christiane, Conejero-Lara, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069472/
https://www.ncbi.nlm.nih.gov/pubmed/33921495
http://dx.doi.org/10.3390/biom11040566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069472/
https://www.ncbi.nlm.nih.gov/pubmed/33921495
http://dx.doi.org/10.3390/biom11040566

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