Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds

Amygdalin (d-Mandelonitrile 6-O-β-d-glucosido-β-d-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enz...

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Autores principales: Jaszczak-Wilke, Ewa, Polkowska, Żaneta, Koprowski, Marek, Owsianik, Krzysztof, Mitchell, Alyson E., Bałczewski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069783/
https://www.ncbi.nlm.nih.gov/pubmed/33924691
http://dx.doi.org/10.3390/molecules26082253
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author Jaszczak-Wilke, Ewa
Polkowska, Żaneta
Koprowski, Marek
Owsianik, Krzysztof
Mitchell, Alyson E.
Bałczewski, Piotr
author_facet Jaszczak-Wilke, Ewa
Polkowska, Żaneta
Koprowski, Marek
Owsianik, Krzysztof
Mitchell, Alyson E.
Bałczewski, Piotr
author_sort Jaszczak-Wilke, Ewa
collection PubMed
description Amygdalin (d-Mandelonitrile 6-O-β-d-glucosido-β-d-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical evidence for the anticancer activity of amygdalin is not fully confirmed. Moreover, high dose exposures to amygdalin can produce cyanide toxicity. The aim of this review is to present the current state of knowledge on the sources, toxicity and anticancer properties of amygdalin, and analytical methods for its determination in plant seeds.
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spelling pubmed-80697832021-04-26 Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds Jaszczak-Wilke, Ewa Polkowska, Żaneta Koprowski, Marek Owsianik, Krzysztof Mitchell, Alyson E. Bałczewski, Piotr Molecules Review Amygdalin (d-Mandelonitrile 6-O-β-d-glucosido-β-d-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical evidence for the anticancer activity of amygdalin is not fully confirmed. Moreover, high dose exposures to amygdalin can produce cyanide toxicity. The aim of this review is to present the current state of knowledge on the sources, toxicity and anticancer properties of amygdalin, and analytical methods for its determination in plant seeds. MDPI 2021-04-13 /pmc/articles/PMC8069783/ /pubmed/33924691 http://dx.doi.org/10.3390/molecules26082253 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jaszczak-Wilke, Ewa
Polkowska, Żaneta
Koprowski, Marek
Owsianik, Krzysztof
Mitchell, Alyson E.
Bałczewski, Piotr
Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title_full Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title_fullStr Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title_full_unstemmed Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title_short Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
title_sort amygdalin: toxicity, anticancer activity and analytical procedures for its determination in plant seeds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069783/
https://www.ncbi.nlm.nih.gov/pubmed/33924691
http://dx.doi.org/10.3390/molecules26082253
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