Internalization of Clostridium botulinum C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes

Clostridium botulinum C2 toxin is a clostridial binary toxin consisting of actin ADP-ribosyltransferase (C2I) and C2II binding components. Activated C2II (C2IIa) binds to cellular receptors and forms oligomer in membrane rafts. C2IIa oligomer assembles with C2I and contributes to the transport of C2...

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Detalles Bibliográficos
Autores principales: Nagahama, Masahiro, Kobayashi, Keiko, Ochi, Sadayuki, Takehara, Masaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069846/
https://www.ncbi.nlm.nih.gov/pubmed/33918753
http://dx.doi.org/10.3390/toxins13040272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069846/
https://www.ncbi.nlm.nih.gov/pubmed/33918753
http://dx.doi.org/10.3390/toxins13040272

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