A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models

SIMPLE SUMMARY: 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is responsible for the production of estrogens estradiol (E2) and 5-androsten-3β,17β-diol (5-diol). This enzyme is therefore a target of choice for the treatment of estrogen-dependent diseases such as breast cancer and endometriosis,...

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Detalles Bibliográficos
Autores principales: Poirier, Donald, Roy, Jenny, Maltais, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069897/
https://www.ncbi.nlm.nih.gov/pubmed/33924352
http://dx.doi.org/10.3390/cancers13081841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069897/
https://www.ncbi.nlm.nih.gov/pubmed/33924352
http://dx.doi.org/10.3390/cancers13081841

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