Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

The conformational state of the activation loop (A-loop) is pivotal for the activity of most protein kinases. Hence, the characterization of the conformational dynamics of the A-loop is important to increase our understanding of the molecular processes related to diseases and to support the discover...

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Detalles Bibliográficos
Autores principales: Musavizadeh, Zahra, Grottesi, Alessandro, Guarguaglini, Giulia, Paiardini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070005/
https://www.ncbi.nlm.nih.gov/pubmed/33921540
http://dx.doi.org/10.3390/biom11040567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070005/
https://www.ncbi.nlm.nih.gov/pubmed/33921540
http://dx.doi.org/10.3390/biom11040567

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