Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis

The newly established CD3FLAG-mIR transgenic mouse model on a C57Bl/6 background has a FLAG tag on the mouse Insulin Receptor (mIR), specifically on T cells, as the FLAG-tagged mIR gene was engineered behind CD3 promoter and enhancer. The IR is a chemotactic molecule for insulin and the Flag-tagged...

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Detalles Bibliográficos
Autores principales: Esakov, Emily, Nandedkar-Kulkarni, Neha, Al-Dieri, Ali G., Hafner, Hannah, Gregg, Brigid, McInerney, Marcia F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070091/
https://www.ncbi.nlm.nih.gov/pubmed/33918805
http://dx.doi.org/10.3390/biom11040552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070091/
https://www.ncbi.nlm.nih.gov/pubmed/33918805
http://dx.doi.org/10.3390/biom11040552

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