Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice

LW6, an (aryloxyacetylamino)benzoic acid derivative, was recently identified to be an inhibitor of hypoxia-inducible factor-1α (HIF-1α), which is an attractive target for cancer therapeutics. Although LW6 is known to act by inhibiting the accumulation of HIF-1α, pharmacokinetics needs to be evaluate...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Yoon, Lee, Kiho, Lee, Kyeong, Kang, Jong Soon, Kim, Min Ju, Yoo, Dong Gu, Kim, Jung Ah, Shin, Eun Jin, Oh, Soo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070284/
https://www.ncbi.nlm.nih.gov/pubmed/33921487
http://dx.doi.org/10.3390/molecules26082226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070284/
https://www.ncbi.nlm.nih.gov/pubmed/33921487
http://dx.doi.org/10.3390/molecules26082226

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