Cargando…
α-Tocopherol Attenuates Oxidative Phosphorylation of CD34(+) Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance
Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells, we studied the impact of αTOA on the metabolic energetic profile and functional properties of hematopoietic stem and prog...
Autores principales: | Rodriguez, Laura, Duchez, Pascale, Touya, Nicolas, Debeissat, Christelle, Guitart, Amélie V., Pasquet, Jean-Max, Vlaski-Lafarge, Marija, Brunet de la Grange, Philippe, Ivanovic, Zoran |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070309/ https://www.ncbi.nlm.nih.gov/pubmed/33920203 http://dx.doi.org/10.3390/biom11040558 |
Ejemplares similares
-
Alpha Lipoic-Acid Potentiates Ex Vivo Expansion of Human Steady-State Peripheral Blood Hematopoietic Primitive Cells
por: Debeissat, Christelle, et al.
Publicado: (2022) -
Repopulating hematopoietic stem cells from steady-state blood before and after ex vivo culture are enriched in the CD34(+)CD133(+)CXCR4(low) fraction
por: Lapostolle, Véronique, et al.
Publicado: (2018) -
Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells
por: Vlaski-Lafarge, Marija, et al.
Publicado: (2020) -
On cancer, stemness, and deep evolutionary homologies
por: Ivanovic, Zoran, et al.
Publicado: (2023) -
Regulatory Crosstalk between Physiological Low O(2) Concentration and Notch Pathway in Early Erythropoiesis
por: Labat, Véronique, et al.
Publicado: (2022)