Monoclonal Antibody Aggregation Associated with Free Radical Induced Oxidation

Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH) as an oxidative stress reagen...

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Detalles Bibliográficos
Autores principales: Zheng, Kai, Ren, Diya, Wang, Y. John, Lilyestrom, Wayne, Scherer, Thomas, Hong, Justin K. Y., Ji, Junyan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070435/
https://www.ncbi.nlm.nih.gov/pubmed/33921206
http://dx.doi.org/10.3390/ijms22083952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070435/
https://www.ncbi.nlm.nih.gov/pubmed/33921206
http://dx.doi.org/10.3390/ijms22083952

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