Design, Synthesis, and Validation of a Novel [(11)C]Promethazine PET Probe for Imaging Abeta Using Autoradiography

Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design an...

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Detalles Bibliográficos
Autores principales: Whitmore, Clayton A., Boules, Mariam I., Behof, William J., Haynes, Justin R., Koktysh, Dmitry, Rosenberg, Adam J., Tantawy, Mohammed N., Pham, Wellington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070574/
https://www.ncbi.nlm.nih.gov/pubmed/33920113
http://dx.doi.org/10.3390/molecules26082182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070574/
https://www.ncbi.nlm.nih.gov/pubmed/33920113
http://dx.doi.org/10.3390/molecules26082182

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