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Design, Synthesis, and Validation of a Novel [(11)C]Promethazine PET Probe for Imaging Abeta Using Autoradiography
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design an...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070574/ https://www.ncbi.nlm.nih.gov/pubmed/33920113 http://dx.doi.org/10.3390/molecules26082182 |