FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

SIMPLE SUMMARY: Overall survival outcomes, despite platinum-based chemotherapy, for patients with advanced ovarian cancer remains poor. Increased DNA repair capacity is a key route to platinum resistance in ovarian cancer. In the current study, we show that FEN1, a key player in DNA repair, is overe...

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Detalles Bibliográficos
Autores principales: Mesquita, Katia A., Ali, Reem, Doherty, Rachel, Toss, Michael S., Miligy, Islam, Alblihy, Adel, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Hickson, Ian, Tatum, Natalie J., Rakha, Emad A., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070745/
https://www.ncbi.nlm.nih.gov/pubmed/33919707
http://dx.doi.org/10.3390/cancers13081866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070745/
https://www.ncbi.nlm.nih.gov/pubmed/33919707
http://dx.doi.org/10.3390/cancers13081866

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