PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway

PRC2 creates the repressive mark histone H3 Lys27 trimethylation. Although PRC2 is involved in various biological processes, its role in glial development remains ambiguous. Here, we show that PRC2 is required for oligodendrocyte (OL) differentiation and myelination, but not for OL precursor formati...

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Detalles Bibliográficos
Autores principales: Wang, Wenxian, Cho, Hyeyoung, Kim, Dongkyeong, Park, Younjung, Moon, Ji Hwan, Lim, Su Jeong, Yoon, Sung Min, McCane, Michael, Aicher, Sue A., Kim, Sangsoo, Emery, Ben, Lee, Jae W., Lee, Seunghee, Park, Yungki, Lee, Soo-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070886/
https://www.ncbi.nlm.nih.gov/pubmed/32937136
http://dx.doi.org/10.1016/j.celrep.2020.108147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070886/
https://www.ncbi.nlm.nih.gov/pubmed/32937136
http://dx.doi.org/10.1016/j.celrep.2020.108147

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