KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer

SIMPLE SUMMARY: The antimalarial drug artesunate also has anticancer activity. Based on what is known about how artesunate works in malaria, we hypothesized that the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway, which is often mutated in non-...

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Detalles Bibliográficos
Autores principales: Hill, Kristen S., McDowell, Anthony, McCorkle, J. Robert, Schuler, Erin, Ellingson, Sally R., Plattner, Rina, Kolesar, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070990/
https://www.ncbi.nlm.nih.gov/pubmed/33920029
http://dx.doi.org/10.3390/cancers13081885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070990/
https://www.ncbi.nlm.nih.gov/pubmed/33920029
http://dx.doi.org/10.3390/cancers13081885

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